BNVCF Supports the Medical College of Wisconsin
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BNVCF Supports the Medical College of Wisconsin
The BNVCF is proud to support the Medical College of Wisconsin and Dr. Michael Dwinell’s laboratory. The BNVCF is supporting the cost of personnel and equipment needed to find ways to detect a predisposition to cancer in support of our mission of “Making a Difference Through Early Detection”.
Dr. Dwinell’s laboratory has previously demonstrated that members of the enzyme family DNA methyltransferase’s cooperatively silence expression of the chemokine CXCL12 and therefore sets in motion an increase in metastatic potential of cancer cells. Our funding will support research in defining the cellular and molecular mechanisms regulating expression and function of these key enzymes. These continued studies will define changes in the enzyme expression and function in order to more clearly detect early changes in the colonic mucosa that may predispose or be suggestive of future cancers.
Additionally, the BNVCF purchased a Nanodrop® ND-1000 Spectrophotometer that will be an essential tool for medical genetics research in Dr. Dwinell’s laboratory. This machine will support the research mentioned above on a daily basis and will enable highly accurate analysis of the nucleic acids (DNA and RNA), proteins, fluorescent dyes and other compounds samples, with remarkable reproducibility. This equipment will increase the ability to isolate minute quantities of RNA and DNA from cancer cell lines and tissue biopsy specimens and strengthen our ability to detect small changes in gene expression.
Related Resources:
- MCOW News Article
An article published in the 2007 issue of the Medical College of Wisconsin News, Volume 14, No. 1 81kb PDF file
- Natural Protein May Halt Colorectal Cancer’s Spread
Medical College of Wisconsin Cancer Center researchers in Milwaukee have learned that a protein, CXCL12, that normally controls intestinal cell movement, has the potential to halt colorectal cancer spreading....19kb PDF file
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